Recent Advances in Transition Metal Complexes with Phenyl Acetic Acid and Pseudo Halogen: Synthesis, Characterization and Applications

Abstract

A well-established strategy is to introduce a biologically relevant organic molecule in coordination sphere of transition metal complexes to increase the selectivity and biocompatibility. Phenylacetic acid (PAA), an organic molecule with a phenyl functional group and a carboxylic acid functional group, is a phenylalanine that is generated from the naturally occurring auxin, which is extensively present in plants. The most promising outcomes in the battle against cancer and microbes come from metal complexes having ligands including bio molecules. In this work we synthesized two complexes of copper with phenyl acetic acid as primary ligand and pseudo halide and orthophenyl diamine as secondary ligands and characterized them by IR, LC-MS, UV and TG-DTA. Later investigated for antimicrobial and cytotoxic activity. The results indicate that these complexes of phenyl acetic acid have proved that they are good antibacterial agents in comparison with the cytotoxicity against MCF-7, A-431, HepG- 2. The complex1 which is having pseudo halide as secondary ligand is found to have good battle against cancer and microbes than the other complex2 which is having orthophenyl diamine as secondary ligand. This is because pseudo halides have ability to disrupt cell membranes, enzymes or metabolic process in microorganisms.

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